Issue No.01 - January-February (2007 vol.24)
Luca Benini , University of Bologna
Carlotta Guiducci , ESPCI-Paris
Christian Paulus , Siemens AG
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/MDT.2007.12
DNA microarrays are among the key technology enablers for the tumultuous development of biology and medicine triggered by high-throughput genomics. As microarray-based methods for analysis and diagnosis become more pervasive, there is an ever-growing demand for low-cost, highly integrated microarrays for point-of-care usage. This article focuses on fully electronic approaches that integrate DNA sensor arrays and circuits for transduction, amplification, digital conversion, and readout of signals on a single CMOS chip. Prototypes of these devices have obtained promising results.
CMOS microarrays, DNA hybridization, label-based DNA chip, label-free DNA chip
Luca Benini, Carlotta Guiducci, Christian Paulus, "Electronic Detection of DNA Hybridization: Toward CMOS Microarrays", IEEE Design & Test of Computers, vol.24, no. 1, pp. 38-48, January-February 2007, doi:10.1109/MDT.2007.12