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Shannon Information in Complete Genomes
Stanford, California August 16-August 19
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/CSB.2004.13324132004 IEEE Computational Systems Bioin ...
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Chang-Heng Chang, Li-Ching Hsieh, Ta-Yuan Chen, Hong-Da Chen, Liaofu Luo, Hoong-Chien Lee, "Shannon Information in Complete Genomes," Computational Systems Bioinformatics Conference, International IEEE Computer Society, pp. 20-30, 2004 IEEE Computational Systems Bioinformatics Conference (CSB'04), 2004.
 
 
BibTex
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@article{ 10.1109/CSB.2004.1332413,
author = {Chang-Heng Chang and Li-Ching Hsieh and Ta-Yuan Chen and Hong-Da Chen and Liaofu Luo and Hoong-Chien Lee},
title = {Shannon Information in Complete Genomes},
journal ={Computational Systems Bioinformatics Conference, International IEEE Computer Society},
volume = {0},
year = {2004},
isbn = {0-7695-2194-0},
pages = {20-30},
doi = {http://doi.ieeecomputersociety.org/10.1109/CSB.2004.1332413},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
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TY - CONF
JO - Computational Systems Bioinformatics Conference, International IEEE Computer Society
TI - Shannon Information in Complete Genomes
SN - 0-7695-2194-0
SP20
EP30
A1 - Chang-Heng Chang,
A1 - Li-Ching Hsieh,
A1 - Ta-Yuan Chen,
A1 - Hong-Da Chen,
A1 - Liaofu Luo,
A1 - Hoong-Chien Lee,
PY - 2004
KW - null
VL - 0
JA - Computational Systems Bioinformatics Conference, International IEEE Computer Society
ER -
 
Chang-Heng Chang, National Central University
Li-Ching Hsieh, National Central University
Ta-Yuan Chen, National Central University
Hong-Da Chen, National Central University
Liaofu Luo, Inner Mongolia University
Hoong-Chien Lee, National Central University and National Center for Theoretical Sciences
Shannon information in the genomes of all completely sequenced prokaryotes and eukaryotes are measured in word lengths of two to ten letters. It is found that in a scale-dependent way, the Shannon information in complete genomes are much greater than that in matching random sequences - thousands of times greater in the case of short words. Furthermore, with the exception of the 14 chromosomes of Plasmodium falciparum, the Shannon information in all available complete genomes belong to a universality class given by an extremely simple formula. The data are consistent with a model for genome growth composed of two main ingredients: random segmental duplications that increase the Shannon information in a scale-independent way, and random point mutations that preferentially reduces the larger-scale Shannon information. The inference drawn from the present study is that the large-scale and coarse-grained growth of genomes was selectively neutral and this suggests an independent corroboration of Kimura?s neutral theory of evolution.
Citation:
Chang-Heng Chang, Li-Ching Hsieh, Ta-Yuan Chen, Hong-Da Chen, Liaofu Luo, Hoong-Chien Lee, "Shannon Information in Complete Genomes," csb, pp.20-30, 2004 IEEE Computational Systems Bioinformatics Conference (CSB'04), 2004
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