We live at a time of rapid change in a world of challenges and contrasts. The opportunities for application of group support systems (GSS) in international contexts are many in number and broad reaching in implication. A methodology for regional development studies has been developed by the ITESM Center for Strategic Studies in Monterrey, Mexico. This paper examines their use of group systems, reports on findings, compares to US findings, and establishes areas of future research. Data gathered in conjunction with a series of GSS sessions on regional development with 293 senior Mexican business and government participants are presented. Discussion focuses on the implications of cultural differences in conjunction with GSS use compared to US groups.