Rapid advances of the Internet, multimedia technology and virtual reality have opened new opportunities for organizations to re-design their traditional functional units often separated by vast distances into a virtually cohesive and cost effective enterprise. This paper proposes an Internet-based framework for supporting collaborative work among human and non-human teleworkers. The proposed framework enables the geographically dispersed organization to distribute work across the Internet and embed intelligent software agents - as teleworkers - capable of supporting decision and negotiation to facilitate implementation of complex distributed decision making. The proposed framework is currently being simulated on a telemedicine project.