This paper proposes CARUSO — a new SoC approach that emphasizes Connectivity, Autonomic computing principles, Real-time, and Ultra-low power requirements. The requirements shall be fulfilled by a multithreaded processor core within a reconfigurable SoC. A helper thread running with low priority in an own thread slot concurrent to the application implements an autonomic manager that monitors the application. A middleware decides if self-optimization, self-configuration, self-protection, or self-healing techniques must be triggered based on the autonomic manager?s information and further application knowledge.