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Parallel RNA Sequence-Structure Alignment
Santa Fe, New Mexico April 26-April 30
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/IPDPS.2004.130320718th International Parallel and Distr ...
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Tong Liu, Nanyang Technological University
Bertil Schmidt, Nanyang Technological University
With the growing number of known RNA genes efficient and accurate computational analysis of RNA sequences is becoming increasingly important. Stochastic context-free grammars (SCFGs) are used as a popular tool to model RNA secondary structures. However, algorithms for aligning an RNA sequence to an SCFG are highly compute-intensive. This has so far limited applications of SCFGs to relatively small problem sizes. In this paper we present the design of a parallel RNA sequence-structure alignment algorithm. Its implementation on a PC cluster leads to significant runtime savings. This makes it possible to compute sequence-structure alignments of even the largest RNAs such as SSU rRNAs and LSU rRNAs in reasonable time.
Citation:
Tong Liu, Bertil Schmidt, "Parallel RNA Sequence-Structure Alignment," ipdps, vol. 10, pp.190b, 18th International Parallel and Distributed Processing Symposium (IPDPS'04) - Workshop 9, 2004
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