Current research on Internet-based distributed systems emphasizes the scalability of overlay topologies for efficient search and retrieval of data items, as well as routing amongst peers. However, most existing approaches fail to address the transport of data across these logical networks in accordance with quality of service (QoS) constraints. Consequently, this paper investigates the use of scalable overlay topologies for routing real-time media streams between publishers and potentially many thousands of subscribers. Specifically, we analyze the costs of using k-ary n-cubes for QoS-constrained routing. Given a number of nodes in a distributed system, we calculate the optimal k-ary n-cube structure for minimizing the average distance between any pair of nodes. Using this structure, we describe a greedy algorithm that selects paths between nodes in accordance with the real-time delays along physical links. We show this method improves the routing latencies by as much as 40%, compared to approaches that do not consider physical link costs. Additionally, we discuss an approach that dynamically repositions nodes in logical space, to improve the likelihood of meeting service requirements on data routed between publishers and subscribers.