loading...
Efficiency of Hybrid Normalization of Microarray Gene Expression: A Simulation Study
Niagara Falls, Ontario, Canada May 21-May 23
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/AINAW.2007.16421st International Conference on Adva ...
 This Article 
 
PDF
HTML
IEEE Xplore Subscribers
 
 Share 
   
 Bibliographic References 
   
 Add to: 
 
Digg
Furl
Spurl
Blink
Simpy
Google
Del.icio.us
Y!MyWeb
 
 Search 
   
Mehdi Pirooznia, University of Southern Mississippi, USA
Youping Deng, University of Southern Mississippi, USA
Microarray experiment's data contain errors, from various sources. The process of identifying and adjusting of systematic variation in intensities between samples on the same slide is known as normalization. We implemented a java application with graphical user interface that allows easy evaluation of errors and the role of hybrid normalization methods to remove the systematic errors from the experiment's data. We calculated true hybridization intensity then applied different additive and multiplicative errors and computed the normalized intensity logged ratio using background subtraction, self-normalization method and dye-flip technique. Results show the efficiency of hybrid normalization method in order to remove error rates from the intensity values.
Citation:
Mehdi Pirooznia, Youping Deng, "Efficiency of Hybrid Normalization of Microarray Gene Expression: A Simulation Study," ainaw, vol. 1, pp.739-744, 21st International Conference on Advanced Information Networking and Applications Workshops (AINAW'07), 2007
Usage of this product signifies your acceptance of the Terms of Use.