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A Novel Electrical Field Bioreactor for Wound Healing Study
May 27-May 30
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.1302008 International Conference on BioM ...
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Gang Yang, Haiyan Long, Jiang Wu, Hua Huang, "A Novel Electrical Field Bioreactor for Wound Healing Study," BioMedical Engineering and Informatics, International Conference on, vol. 2, pp. 548-552, 2008 International Conference on BioMedical Engineering and Informatics, 2008.
 
 
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@article{ 10.1109/BMEI.2008.130,
author = {Gang Yang and Haiyan Long and Jiang Wu and Hua Huang},
title = {A Novel Electrical Field Bioreactor for Wound Healing Study},
journal ={BioMedical Engineering and Informatics, International Conference on},
volume = {2},
year = {2008},
isbn = {978-0-7695-3118-2},
pages = {548-552},
doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.130},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
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TY - CONF
JO - BioMedical Engineering and Informatics, International Conference on
TI - A Novel Electrical Field Bioreactor for Wound Healing Study
SN - 978-0-7695-3118-2
SP548
EP552
A1 - Gang Yang,
A1 - Haiyan Long,
A1 - Jiang Wu,
A1 - Hua Huang,
PY - 2008
KW - wound healing
KW - electric field
KW - bioreactor
KW - galvanotaxis
KW - cells migration
VL - 2
JA - BioMedical Engineering and Informatics, International Conference on
ER -
 
Wound healing is essential for maintaining the integrity of multicellular organisms. The disruption of an epithelial layer instantaneously generates endogenous electric fields, which play a key role in wound healing. In vitro, a variety of cells respond to DC electric fields of physiological strength by directional movement. Such experiments involve culturing cells in specially designed galvanotaxis chambers connected to a DC power supply. In this article, we introduce a novel electrical field bioreactor with a specially designed galvanotaxis chamber. The EFs in galvanotaxis chamber are uniform parallel field and the current density distribution are demonstrated by ANSYS 10.0 electrical field simulation software. For testifying the function of the novel galvanotaxis bioreactor, we cultured Hy926 cells for 12 hours under a online time-lapse microscope. Cells migration tracks are recorded and handled by Image-pro plus5.0 analysis software. The experiment results show Hy926 cells have obvious directional migration to the cathode.
Index Terms:
wound healing, electric field, bioreactor, galvanotaxis, cells migration
Citation:
Gang Yang, Haiyan Long, Jiang Wu, Hua Huang, "A Novel Electrical Field Bioreactor for Wound Healing Study," bmei, vol. 2, pp.548-552, 2008 International Conference on BioMedical Engineering and Informatics, 2008
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