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Caspase-8 Regulates Caspase-3 and Rb Respectively in Fas- and Actinomycin D-Mediated Apoptosis Pathway in Human Hepatoma Bel-7402 Cells
May 27-May 30
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.1462008 International Conference on BioM ...
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Yu Wang, Liguang Sun, Chunhui Xia, Liping Ye, Biao Wang, "Caspase-8 Regulates Caspase-3 and Rb Respectively in Fas- and Actinomycin D-Mediated Apoptosis Pathway in Human Hepatoma Bel-7402 Cells," BioMedical Engineering and Informatics, International Conference on, vol. 2, pp. 848-852, 2008 International Conference on BioMedical Engineering and Informatics, 2008.
 
 
BibTex
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@article{ 10.1109/BMEI.2008.146,
author = {Yu Wang and Liguang Sun and Chunhui Xia and Liping Ye and Biao Wang},
title = {Caspase-8 Regulates Caspase-3 and Rb Respectively in Fas- and Actinomycin D-Mediated Apoptosis Pathway in Human Hepatoma Bel-7402 Cells},
journal ={BioMedical Engineering and Informatics, International Conference on},
volume = {2},
year = {2008},
isbn = {978-0-7695-3118-2},
pages = {848-852},
doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.146},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
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TY - CONF
JO - BioMedical Engineering and Informatics, International Conference on
TI - Caspase-8 Regulates Caspase-3 and Rb Respectively in Fas- and Actinomycin D-Mediated Apoptosis Pathway in Human Hepatoma Bel-7402 Cells
SN - 978-0-7695-3118-2
SP848
EP852
A1 - Yu Wang,
A1 - Liguang Sun,
A1 - Chunhui Xia,
A1 - Liping Ye,
A1 - Biao Wang,
PY - 2008
KW - null
VL - 2
JA - BioMedical Engineering and Informatics, International Conference on
ER -
 
Aim: To investigate whether caspase-8 can regulate caspase-3 and Rb expression respectively in Fas- and Actinomycin D (AD)-mediated apoptosis pathway in Human Hepatoma Bel-7402 Cells. Methods: Bel-7402 cells were treated with Fas-AD in the presence/absence of caspase-8 inhibitor Ac-IEFD-cho. Cell apoptosis was evaluated by flow cytometry (FCM). The expressions of caspase-3 and RB were determined by Western Blot and RT-PCR, respectively. Results: Compared with the control group and the fas group, the cell apoptosis rate and the expressions of activated caspase-3 and RB increased significantly after Bel-7402 cells were treated with Fas-AD. However, when Bel-7402 cells were treated with Fas-AD in the presence of the inhibitors of Ac-IEFD-cho, the cell apoptosis rate and the expressions of activated caspase-3 and RB decreased significantly. Conclusion: caspase-8 can regulate caspase-3 and Rb respectively in Fas- and AD-mediated apoptosis pathway in Bel-7402 cells.
Citation:
Yu Wang, Liguang Sun, Chunhui Xia, Liping Ye, Biao Wang, "Caspase-8 Regulates Caspase-3 and Rb Respectively in Fas- and Actinomycin D-Mediated Apoptosis Pathway in Human Hepatoma Bel-7402 Cells," bmei, vol. 2, pp.848-852, 2008 International Conference on BioMedical Engineering and Informatics, 2008
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