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Parameter Estimation of Kinetic Rates in Stochastic Reaction Networks by the EM Method
May 27-May 30
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.2372008 International Conference on BioM ...
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Andr? Horv?th, Daniele Manini, "Parameter Estimation of Kinetic Rates in Stochastic Reaction Networks by the EM Method," BioMedical Engineering and Informatics, International Conference on, vol. 1, pp. 713-717, 2008 International Conference on BioMedical Engineering and Informatics, 2008.
 
 
BibTex
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@article{ 10.1109/BMEI.2008.237,
author = {Andr? Horv?th and Daniele Manini},
title = {Parameter Estimation of Kinetic Rates in Stochastic Reaction Networks by the EM Method},
journal ={BioMedical Engineering and Informatics, International Conference on},
volume = {1},
year = {2008},
isbn = {978-0-7695-3118-2},
pages = {713-717},
doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.237},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
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TY - CONF
JO - BioMedical Engineering and Informatics, International Conference on
TI - Parameter Estimation of Kinetic Rates in Stochastic Reaction Networks by the EM Method
SN - 978-0-7695-3118-2
SP713
EP717
A1 - Andr? Horv?th,
A1 - Daniele Manini,
PY - 2008
KW - stochastic reaction network
KW - kinetic rate constants
KW - parameter estimation
VL - 1
JA - BioMedical Engineering and Informatics, International Conference on
ER -
 
Gillespie's algorithm serves to simulate a network of stochastic reactions with given initial quantities and kinetic rate constants.??In this paper we consider the estimation of the kinetic rate constants of the reactions based on a set of discrete observations generated by Gillespie's algorithm. In particular, we present an Expectation Maximisation (EM) method to perform maximum likelihood estimation of the rate constants.??Applicability of the method is tested on a simple reaction network.
Index Terms:
stochastic reaction network, kinetic rate constants, parameter estimation
Citation:
Andr? Horv?th, Daniele Manini, "Parameter Estimation of Kinetic Rates in Stochastic Reaction Networks by the EM Method," bmei, vol. 1, pp.713-717, 2008 International Conference on BioMedical Engineering and Informatics, 2008
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