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Optimization of Production of PLA Microbubble Ultrasound Contrast Agents for Hydroxycamptothecin Delivery
May 27-May 30
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.3402008 International Conference on BioM ...
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Jie Pan, Zhenqing Hou, Peijuan Zhu, Yange Wang, Qian Wang, Qiqing Zhang, "Optimization of Production of PLA Microbubble Ultrasound Contrast Agents for Hydroxycamptothecin Delivery," BioMedical Engineering and Informatics, International Conference on, vol. 1, pp. 400-406, 2008 International Conference on BioMedical Engineering and Informatics, 2008.
 
 
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@article{ 10.1109/BMEI.2008.340,
author = {Jie Pan and Zhenqing Hou and Peijuan Zhu and Yange Wang and Qian Wang and Qiqing Zhang},
title = {Optimization of Production of PLA Microbubble Ultrasound Contrast Agents for Hydroxycamptothecin Delivery},
journal ={BioMedical Engineering and Informatics, International Conference on},
volume = {1},
year = {2008},
isbn = {978-0-7695-3118-2},
pages = {400-406},
doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.340},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
x 
 
TY - CONF
JO - BioMedical Engineering and Informatics, International Conference on
TI - Optimization of Production of PLA Microbubble Ultrasound Contrast Agents for Hydroxycamptothecin Delivery
SN - 978-0-7695-3118-2
SP400
EP406
A1 - Jie Pan,
A1 - Zhenqing Hou,
A1 - Peijuan Zhu,
A1 - Yange Wang,
A1 - Qian Wang,
A1 - Qiqing Zhang,
PY - 2008
KW - Ultrasound contrast agent; Poly
VL - 1
JA - BioMedical Engineering and Informatics, International Conference on
ER -
 
In this paper, ultrasound contrast agents based on a high molecular polymer-poly lactic acid (PLA) and loaded with Hydroxycamptothecin (HCPT) were prepared by combining ultrasound methodand a Shirasu Porous Glass (SPG) membrane emulsification technique. A special focus was on the optimization of production of HCPT-PLA microbubbles. Different factors, such as the power and the time of ultrasonic action, the ratio of inner aqueous phase against outer oil phase, and the concentration of PLA were evaluated, and the average size of HCPT-PLA microbubbles, the drug carrying efficiency, as well as the acoustically triggered drug release at 3kHz ultrasound were determined. The study showed that the HCPT-PLA microbubbles prepared using our optimized conditions, were sphere-like in shape with a mean diameter of 1-7μm. The drug loading efficiency reached up to 56.48%. In vitro, the drug release of HCPT-PLA microbubbles increased significantly at 3kHz ultrasound for 30s compared with that of ultrasound-free condition. In conclusion, the HCPT-PLA microbubbles has the characteristics desirable for an intravenously administered ultrasound contrast agent for further clinical use.
Index Terms:
Ultrasound contrast agent; Poly
Citation:
Jie Pan, Zhenqing Hou, Peijuan Zhu, Yange Wang, Qian Wang, Qiqing Zhang, "Optimization of Production of PLA Microbubble Ultrasound Contrast Agents for Hydroxycamptothecin Delivery," bmei, vol. 1, pp.400-406, 2008 International Conference on BioMedical Engineering and Informatics, 2008
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