A Method to Correct Systematic Bias in Affymetrix SNP Arrays

May 27-May 30

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http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.41

2008 International Conference on BioM ...

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	Lin Wan, Wenjiang J. Fu, Minghua Deng, Minping Qian, "A Method to Correct Systematic Bias in Affymetrix SNP Arrays," BioMedical Engineering and Informatics, International Conference on, vol. 1, pp. 442-446, 2008 International Conference on BioMedical Engineering and Informatics, 2008.

	BibTex	x
	@article{ 10.1109/BMEI.2008.41, author = {Lin Wan and Wenjiang J. Fu and Minghua Deng and Minping Qian}, title = {A Method to Correct Systematic Bias in Affymetrix SNP Arrays}, journal ={BioMedical Engineering and Informatics, International Conference on}, volume = {1}, year = {2008}, isbn = {978-0-7695-3118-2}, pages = {442-446}, doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.41}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, }

	RefWorks Procite/RefMan/Endnote	x
	TY - CONF JO - BioMedical Engineering and Informatics, International Conference on TI - A Method to Correct Systematic Bias in Affymetrix SNP Arrays SN - 978-0-7695-3118-2 SP442 EP446 A1 - Lin Wan, A1 - Wenjiang J. Fu, A1 - Minghua Deng, A1 - Minping Qian, PY - 2008 KW - Affymetrix SNP arrays KW - copy number estimation KW - systematic bias VL - 1 JA - BioMedical Engineering and Informatics, International Conference on ER -

Lin Wan

Wenjiang J. Fu

Minghua Deng

Minping Qian

Affymetrix SNP arrays are important tools and widely used for both genotyping and copy number estimation. We found previously that systematic bias exists in Affymetrix SNP arrays and leads to loss of accuracy in copy number estimations. In this paper, we showed that systematic bias within SNP arrays is multiplicative effect (or additive effects in the log scale) to probe intensities. Based on this observation, a method was introduced to correct the systematic bias within SNP arrays.

Index Terms:

Affymetrix SNP arrays, copy number estimation, systematic bias

Citation:

Lin Wan, Wenjiang J. Fu, Minghua Deng, Minping Qian, "A Method to Correct Systematic Bias in Affymetrix SNP Arrays," bmei, vol. 1, pp.442-446, 2008 International Conference on BioMedical Engineering and Informatics, 2008

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