Abstract: The purpose of this paper is to establish a new method to determine the safety of a hospital building. A good hospital building should be capable of resisting various loadings such as dead load, live load, wind load, earthquake load, flooding load, thermal load and others. A safety building can be designed using a basic structural analysis. Most loadings vary with time. It is evident that a building needs a simultaneous dynamic analysis, These lateral loadings are random phenomena. Probability theory can be used to analyze these loadings. By using the method of Load and Resistance Factor Design (LRFD), we derive a reliability index, which is quite useful in structural design and can be used to indicate the consistency of safety for a hospital.