Abstract: A new research resource has been developed, allowing organizations with limited facilities for PK/PD analysis to develop large and nonlinear non-parametric population models. The infrastructure described below is flexible, reliable, and secure. These resources are in use today by researchers in a number organizations and countries. Satellite installations continue to grow both nationally and internationally. The computational systems currently made available through the web interfaces include the worlds 8th largest supercomputer, smaller supercomputers, and Beowulf systems. In the first section we give a formulation of the problem. Then we give a description of the infrastructures to overcome the problem. The last section contains an example of how the system is being used today.