This paper reviews the ?database interoperability? problems and suggests a framework for integrating the molecular biology databases. The paper suggested a component database for gene mutation data which is subject oriented and dedicated to a particular research laboratory and outlined how to develop a cooperative environment for the molecular biology databases to share information on a common view. The paper has also established the concept of image object keying for multidatabase query and it has proposed a matching algorithm using gel electrophoresis image. This image object keying method will replace the conventional SQL scripts for multidatabase query.