Proteome Profiling without Selection Bias

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http://doi.ieeecomputersociety.org/10.1109/CBMS.2006.134

19th IEEE Symposium on Computer-Based ...

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	Annalisa Barla, Bettina Irler, Stefano Merler, Giuseppe Jurman, Silvano Paoli, Cesare Furlanello, "Proteome Profiling without Selection Bias," Computer-Based Medical Systems, IEEE Symposium on, pp. 941-946, 19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06), 2006.

	BibTex	x
	@article{ 10.1109/CBMS.2006.134, author = {Annalisa Barla and Bettina Irler and Stefano Merler and Giuseppe Jurman and Silvano Paoli and Cesare Furlanello}, title = {Proteome Profiling without Selection Bias}, journal ={Computer-Based Medical Systems, IEEE Symposium on}, volume = {0}, year = {2006}, issn = {1063-7125}, pages = {941-946}, doi = {http://doi.ieeecomputersociety.org/10.1109/CBMS.2006.134}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, }

	RefWorks Procite/RefMan/Endnote	x
	TY - CONF JO - Computer-Based Medical Systems, IEEE Symposium on TI - Proteome Profiling without Selection Bias SN - 1063-7125 SP941 EP946 A1 - Annalisa Barla, A1 - Bettina Irler, A1 - Stefano Merler, A1 - Giuseppe Jurman, A1 - Silvano Paoli, A1 - Cesare Furlanello, PY - 2006 KW - null VL - 0 JA - Computer-Based Medical Systems, IEEE Symposium on ER -

Annalisa Barla, ITC-irst, Italy

Bettina Irler, ITC-irst, Italy

Stefano Merler, ITC-irst, Italy

Giuseppe Jurman, ITC-irst, Italy

Silvano Paoli, ITC-irst, Italy

Cesare Furlanello, ITC-irst, Italy

In this paper, we present a method for predictive profiling of mass spectrometry data. The method integrates a spectra preprocessing pipeline with a complete validation setup aimed at identifying the discriminating peaks and at providing an unbiased estimate of the predictive classification error, based on SVM classifiers and on Entropy-based RFE procedure. A particular emphasis is placed upon avoiding selection bias effects throughout all the analysis steps, from preprocessing to peak importance ranking.

Citation:

Annalisa Barla, Bettina Irler, Stefano Merler, Giuseppe Jurman, Silvano Paoli, Cesare Furlanello, "Proteome Profiling without Selection Bias," cbms, pp.941-946, 19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06), 2006

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