The Cybermedia Center, Osaka University (CMC) is a research institution that offers resource with knowledge and technology of all advanced research in the area of large-scale computation, information and communication, multimedia content and education. Currently, CMC involves in Japanese national grid projects such as JGN II (Japan Gigabit Network) and BioGrid. Not limited to Japan, CMC also takes an active part in international activities such as PRAGMA. In these projects and international collaboration, CMC has developed the Grid system that allows scientists to perform their analysis by remotely controlling the world-largest ultra-high voltage electron microscope located in Osaka University. On the other, CMC has been taking a leading role at BioGrid sharing experience and knowledge on the system development for biology. In this paper, we will describe BioGrid project overview and introduce progress of Telescience group which collaborates with Telescience project lead by National Center for Microscopy and Imaging Research (NCMIR).