Recently, ontology has become the key technique to annotate semantics and provide a common foundation for various complex resources on the semantic web. Efficient registration is the fundamental basis of other applications based on ontology, but extant registry mechanisms are insufficient to register semantic information and enable interoperation based on them. So in this paper, MFI4Onto is proposed as a common framework to register ontology and its evolution information for semantic interoperation between ontologies and information systems based on them. Furthermore, MFI4Onto can also be extended to coordinate with ebXML and enhance its capability for complex resources. Under the guidance of MFI4Onto, it is feasible to perform semantic interoperation between heterogeneous registries on the semantic web.