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Accurate Prediction of Orthologous Gene Groups in Microbes
Stanford, California August 08-August 11
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/CSB.2005.102005 IEEE Computational Systems Bioin ...
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Hongwei Wu, Fenglou Mao, Victor Olman, Ying Xu, "Accurate Prediction of Orthologous Gene Groups in Microbes," Computational Systems Bioinformatics Conference, International IEEE Computer Society, pp. 73-79, 2005 IEEE Computational Systems Bioinformatics Conference (CSB'05), 2005.
 
 
BibTex
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@article{ 10.1109/CSB.2005.10,
author = {Hongwei Wu and Fenglou Mao and Victor Olman and Ying Xu},
title = {Accurate Prediction of Orthologous Gene Groups in Microbes},
journal ={Computational Systems Bioinformatics Conference, International IEEE Computer Society},
volume = {0},
year = {2005},
isbn = {0-7695-2344-7},
pages = {73-79},
doi = {http://doi.ieeecomputersociety.org/10.1109/CSB.2005.10},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
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TY - CONF
JO - Computational Systems Bioinformatics Conference, International IEEE Computer Society
TI - Accurate Prediction of Orthologous Gene Groups in Microbes
SN - 0-7695-2344-7
SP73
EP79
A1 - Hongwei Wu,
A1 - Fenglou Mao,
A1 - Victor Olman,
A1 - Ying Xu,
PY - 2005
KW - null
VL - 0
JA - Computational Systems Bioinformatics Conference, International IEEE Computer Society
ER -
 
Hongwei Wu, University of Georgia and Oak Ridge National Laboratory
Fenglou Mao, Oak Ridge National Laboratory
Victor Olman, Oak Ridge National Laboratory
Ying Xu, University of Georgia and Oak Ridge National Laboratory
We present a new computational method for the prediction of orthologous gene groups for microbial genomes based on the prediction of co-occurrences of homologous genes. The method is inspired by the observation that homologous genes are highly likely to be orthologous if their neighboring genes are also homologous. Based on co-occurrences of homologous genes, we have grouped the (predicted) operons of 77 selected sequenced microbial genomes so that operons of the same group are highly likely to be functionally similar or related. We then cluster the homologous genes in the same operon group so that genes of the same cluster are highly likely to be similar in terms of their sequences and functions, i.e., they are predicted to be orthologous genes. By comparing our predicted orthologous gene groups with the COG assignments and NCBI annotations, we conclude that our method is promising to provide more accurate and specific predictions than the existing methods.
Citation:
Hongwei Wu, Fenglou Mao, Victor Olman, Ying Xu, "Accurate Prediction of Orthologous Gene Groups in Microbes," csb, pp.73-79, 2005 IEEE Computational Systems Bioinformatics Conference (CSB'05), 2005
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