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Protein Secondary Structure Prediction Using Support Vector Machine With a PSSM Profile and an Advanced Tertiary Classifier
Stanford, California August 08-August 11
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/CSBW.2005.1142005 IEEE Computational Systems Bioin ...
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Hae-Jin Hu, Department of Computer Science,Georgia State University, Atlanta
Phang C. Tai, Department of Biology,Georgia State University, Atlanta
Robert Harrison, Department of Biology,Georgia State University, Atlanta
Jieyue He, Southeast University, Nanjing
Yi Pan, Department of Computer Science, Georgia State University, Atlanta

In this study, the support vector machine (SVM) is applied as a learning machine for the secondary structure prediction. As an encoding scheme for training the SVM, position-specific scoring matrix (PSSM) is adopted. To improve the prediction accuracy, three optimization processes such as encoding scheme, sliding window size and parameter optimization are performed. For the multi-class classification, the results of three one-versus-one binary classifiers (H/E, E/C and C/H) are combined using our new tertiary classifier called SVM_Represent. By applying this new tertiary classifier, the Q3 prediction accuracy reaches 89.6% on the RS126 dataset and 90.1% on the CB513 dataset. Also the Segment Overlap Measure (SOV) is 85.0% on the RS126 dataset and 85.7% on the CB513 dataset. Compared with the existing best prediction methods, our new prediction algorithm improves the accuracy about 13% in terms of Q3 and SOV, the two most commonly used accuracy measures.

Citation:
Hae-Jin Hu, Phang C. Tai, Robert Harrison, Jieyue He, Yi Pan, "Protein Secondary Structure Prediction Using Support Vector Machine With a PSSM Profile and an Advanced Tertiary Classifier," csbw, pp.213-214, 2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05), 2005
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