Coronary heart disease was the single largest cause of sudden death in Australia in 2002. Computed tomography angiography (CTA) provides high resolution, high contrast images of the thoracic cavity, and as such has emerged as the imaging modality of choice for diagnosing and planning treatment for coronary heart disease. However, radiologists and cardiac surgeons require tools to easily identify possible stenosis (narrowed or constricted coronary vessels) in such CTA datasets. We present a method which allows users to interactively visualise a specific three-dimensional region of interest (ROI). In our example, segmentation methods are applied to isolate the coronary vessels, which in turn are visually enhanced using various perceptual cues. The segmentation is achieved using a combination of thresholding, region-growing, and morphological operations. The perceptual enhancement is realized by fusing direct volume rendered images using weighting factors determined by the segmented regions. The user can allow for the easy dissemination of relevant information by adjusting ?transfer functions? to control the degree of ROI enhancement. This approach requires only roughly segmented regions of interest, and allows for the 3D visualisation of calcifications within vessels. This proposed method has significant potential for helping to facilitate the efficient treatment for coronary heart disease. Furthermore, it can be implemented at interactive framerates on comparatively cheap, desktop computing hardware making it readily accessible.