eScience applications need to use distributed Grid environments where each component is an individual or cluster of multicore machines. These are expected to have 64-128 cores 5 years from now and need to support scalable parallelism. Users will want to compose heterogeneous components into single jobs and run seamlessly in both distributed fashion and on a future "Grid on a chip" with different subsets of cores supporting individual components. We support this with a simple programming model made up of two layers supporting traditional parallel and Grid programming paradigms (workflow) respectively. We examine for a parallel clustering application, the Concurrency and Coordination Runtime CCR from Microsoft as a multi-paradigm runtime that integrates the two layers. Our work uses managed code (C#) and for AMD and Intel processors shows around a factor of 5 better performance than Java. CCR has MPI pattern and dynamic threading latencies of a few microseconds that are competitive with the performance of standard MPI for C.