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Local Alignments of DNA Sequences with the Connex Array
Bucharest, Romania August 01-August 03
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/ICCGI.2006.47International Multi-Conference on Com ...
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Dominique Thiebaut, Smith College, Northampton, MA, USA
Gheorghe Stefan, Politehnica University of Bucharest, Romania
Mihaela Malita, St Anselm College, Manchester, NH, USA
This paper presents a heuristic for finding close to optimal solutions to the local alignment problem of two DNA sequences, and more precisely to the gene prediction problem on the Connex Array circuit, a new hierarchical parallel in-memory device. Though not optimal, the solutions generated by our algorithm compare well with those generated by other algorithms in the public domain. When aligning a probe of N symbols to a target of M symbols, the algorithm has a theoretical time complexity of O(N log(N)), with a small constant of proportionality, and requires no preprocessing of the data. However, experimental results exhibit quasi-linear time complexity.
Citation:
Dominique Thiebaut, Gheorghe Stefan, Mihaela Malita, "Local Alignments of DNA Sequences with the Connex Array," iccgi, pp.50, International Multi-Conference on Computing in the Global Information Technology - (ICCGI'06), 2006
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