There has been increasing pressure on the health care sector to adopt information technologies to rationalize service delivery and increase service quality. Medical information systems need to be highly interoperable and effectively manage complex information of great sensitivity. Moreover, they have to be optimized for usability in a highly complex knowledge base and agile work environment. This tutorial introduces key concepts, methods and techniques essential for engineering clinical information systems, in particular electronic medical records. It targets participants with basic software engineering knowledge who are or will be involved in development, maintenance, evolution or research of medical software.