This paper discusses our approach to the problem of arranging a Bluetooth based positioning system capable of providing people coordinates in a given area with an accuracy as high as possible. Our strategy focuses on optimizing the disposition of a minimal number of available Bluetooth base stations in a subset of locations which are the only ones permitted by site characteristics and constraints. We used a genetic algorithm to this purpose and a layout chromosome whose best evolution suggested us how to deploy a minimal set of Bluetooth base stations. As a case study, we discuss our experiments and results which deal with a late middle age castle in Sicily where we carried out many trials.